For research purposes only

Cat. No BA94673142

Availability - up to 100 mg in stock
- larger amount can be synthesized in 6 weeks

Description of biological activity

Selective ligand for D3 dopamine receptors (compared to D2). In a radioligand [125I]-iodosulpiride displacement assay (on hD3 and hD2 receptors transfected into Chinese hamster ovary (CHO) cells) the compound showed pKi(hD3)/pKi(hD2) = 9.0/7.5 [1].

TECHNICAL INFORMATION

3a(R)-9b(S)-N-{4-[2-(8-Cyano-1,3a,4,9b-tetrahydro-3H-5-oxa-2-aza-cyclopenta[a]naphthalen-2-yl)-ethyl]-phenyl}-acetamide selective ligand for D3 dopamine receptors (compared to D2).

IUPAC Name: 3a(R)-9b(S)-N-{4-[2-(8-Cyano-1,3a,4,9b-tetrahydro-3H-5-oxa-2-aza-cyclopenta[a]naphthalen-2-yl)-ethyl]-phenyl}-acetamide

CAS Number: 245514-31-2

Purity: > 96% chemical purity (LCMS)
> 98% ee (chiral LC)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. Bioorg. Med. Chem. Lett. 1999, 9 (14), 2059-2064
2. J. Med Chem. 1996, 39, 4233-4237

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