NU7026

For research purposes only

Cat. No BA142114778

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Description of biological activity

NU 7026 is a selective DNA-PK inhibitor with enhanced activity compared to related enzymes ATM, ATR, mTOR, and PI3Ks.
IC50: 0.1 μM (DNA-PK) [1], 11.1 μM (PI3Kα) [2]
Taget: DNA-dependent protein kinase (DNA-PK), Phosphatidylinositol 3-Kinase α (PI3Kα)

Biological target category

Phosphatidylinositol 3-kinase-related kinases (PIKKs), Phosphoinositide 3-kinases PI3K(s)

TECHNICAL INFORMATION

NU7026, 2-Morpholino-4H-naphtho<1,2-b>pyran-4-one, 7,8-benzo-2-(morpholin-4-yl)chromen-4-one, 2-(morpholin-4-yl)benzo[h]chromen-4-one Phosphatidylinositol 3-Kinase α (PI3Kα) inhibitor.

IUPAC Name: NU7026, 2-Morpholino-4H-naphtho<1,2-b>pyran-4-one, 7,8-benzo-2-(morpholin-4-yl)chromen-4-one, 2-(morpholin-4-yl)benzo[h]chromen-4-one

CAS Number: 154447-35-5

Purity: > 98% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. J. Med. Chem. 2005, 48, 569-585
2. Blood 2004, 103, 4659
3. Cancer Res. 2003, 63, 6008
4. IL Farmaco 1998, 53, 494 (antiproliferative properties)

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