For research purposes only

Cat. No BA94673128

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Description of biological activity

Potent and selective inhibitor of the Hepatitis C Virus RNA-dependent RNA Polymerase NS5B In vitro assays used incorporation of [33P]-GMP into RNA followed by absorption of biotin labelled RNA polymer by streptavidin containing SPA beads [WO2006/45613 A1, 2006]. The IC50 was found to be < 0.75 μmol/l (genotype 1a C-Terminally truncated (delta21) from strain H77) and < 0.20 μmol/l (genotype 1b full-length). Anti-HCV agent.

Keywords: Antiviral

TECHNICAL INFORMATION

(2R,4S,5R)-1-(3-methoxy-4-tert-butylbenzoyl)-4-(methoxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid potent and selective inhibitor of the Hepatitis C Virus RNA-dependent RNA Polymerase NS5B

IUPAC Name: (2R,4S,5R)-1-(3-methoxy-4-tert-butylbenzoyl)-4-(methoxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

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