For research purposes only

Cat. No BA94673146

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Description of biological activity

Potent NMDA receptor agonist. The compound is a very potent agonist, approximately 20 times more active than NMDA at NMDA receptors, while the corresponding cis isomer was 1/3 as potent as NMDA. Selectivity over different glutamate binding (NR2) subunits of the receptor (NR2A-D) has been identified [3]; in an essay (two-electrode voltage-clamp recordings of X. laevis oocytes coexpressing the NR1 subunit together with the NR2A, NR2B, NR2C, or NR2D subunit), the EC50 were determined to be correspondingly 3.06 μmol/l, 0.995 μmol/l, 1.15 μmol/l, and 0.512 μmol/l.

TECHNICAL INFORMATION

trans-ACBD, trans-1-aminocyclobutane-1,3-dicarboxylic acid hydrochloride potent NMDA receptor agonist.

IUPAC Name: trans-ACBD, trans-1-aminocyclobutane-1,3-dicarboxylic acid hydrochloride

CAS Number: 1212359-85-7

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. J. Med. Chem. 1990, 33, 2905
2. Eur. J. Pharmacol. 1990, 182, 397
3. Molecular Pharmacology 2007, 907-920
4. Org. Prep. Proc. Int. 1995, 27, 185-212

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