For research purposes only

Cat. No BA94673152

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Description of biological activity

Histamine Receptor antagonist In a radioligand assay [3] the compound showed Ki = 0.45 nM for human H3 and Ki = 3.22 nM for rat H3.

TECHNICAL INFORMATION

4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile (ABT-239) Histamine Receptor antagonist

IUPAC Name: 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile (ABT-239)

CAS Number: 460746-46-7

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. Bioorg. Med. Chem. Lett. 2007,В 17,В 1443-1446
2. Tetrahedron, 2006, 62, 4584-4589
3. J. Med. Chem. 2005, 48, 38-55
4. J. Pharm. Exp. Therap. 2005, 313, 176-190
5. J. Pharm. Exp. Therap. 2005, 313, 165-175

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