For research purposes only

Cat. No BA119944940

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Description of biological activity

Potent and reversible inhibitor of Caspase-1 and Caspase-4. In an assay [US2009/68105 A1, 2009] the compound displayed IC50 8.1 nm/l for Caspase-1. Strongly inhibits anti-Fas induced apoptosis in L929 Fas cells. In vitro reversible inhibitor of interleukin-1β-converting enzyme (ICE) from THP-1 cells. In an assay, the compound inhibited mouse fibroblast taxotere induced cell death (the cells were pretreated with 600 μmol/l of the compound for 2 h then treated with 1E-2 -1E4 ng/ml taxotere for 24 h and cell viability measured with MTT assay and Hoechst 33342 staining procedures; control cells were pretreated with DMSO then treated with taxotere).

Keywords: Anti-cancer


L-709049, Ac-Tyr-Val-Ala-Asp-aldehyde potent and reversible inhibitor of Caspase-1 and Caspase-4.

IUPAC Name: L-709049, Ac-Tyr-Val-Ala-Asp-aldehyde

CAS Number: 143313-51-3

Purity: > 96% chemical purity (LCMS)
> 95% de


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2. Biochemistry 1998, 37, 8508-8515
3. J. Biol. Chem.,1998, 273, 32608-32613
4. J. Biol. Chem.,1997, 272, 17907-17911
5. Biochemistry,1994, 33, 3934-3940
6. Trends Biochem. Sci.,1997, 22, 299-306 (review on caspases)

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