For research purposes only

Cat. No BA94673162

Availability - up to 100 mg in stock
- larger amount can be synthesized in 8 weeks

Description of biological activity

The compound modulates the functional interaction of the Agouti related protein (AgRP) with melanocortin receptors. The AgRP is an inverse agonist of the MC-R4 and have been shown to be a key regulator of human body weight [Science, 278, 135-138]. In an assay using HEK293 cells stably expressing melanocortin receptor subtype MC-4R of human the compound showed EC50 < 15 μmol/l [WO2005/103022 A1, 2005].

Keywords: Modulators Obesity

TECHNICAL INFORMATION

sodium 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-propionate modulates interaction of AgRP with melanocortin receptors.

IUPAC Name: sodium 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-propionate

CAS Number: 868589-35-9

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

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