For research purposes only

Cat. No BA94673163

Availability - 10 mg in stock
- larger amount can be synthesized in 8 weeks

Description of biological activity

The compound inhibits decaprenylphosphoryl-β-d-ribose 2´-epimerase that abolishes the formation of decaprenylphosphoryl arabinose, a key precursor required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. Antimycobacterial agent that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of tuberculosis [US2009/239851 A1, 2009, WO2007/134625 A1, 2007].

TECHNICAL INFORMATION

2-(2-methyl-1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one (BTZ043) Inhibits decaprenylphosphoryl-β-d-ribose 2´-epimerase

IUPAC Name: 2-(2-methyl-1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one (BTZ043)

CAS Number: 957217-65-1

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. Science 2009, 324, 801-804

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