For research purposes only

Cat. No BA94673177

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Description of biological activity

High-affinity Thyroid Hormone Receptor antagonist. Assays were performed in vitro on human thyroid hormone receptor β1 (IC50 22 nmol/l) and human thyroid hormone receptor α1 (IC50 36 nmol/l) [1].

TECHNICAL INFORMATION

3-{3,5-dibromo-4-[4-hydroxy-3-isopropyl-5-((E)-2-pyridin-4-yl-vinyl)phenoxy]phenyl}propionic acid high-affinity Thyroid Hormone Receptor antagonist.

IUPAC Name: 3-{3,5-dibromo-4-[4-hydroxy-3-isopropyl-5-((E)-2-pyridin-4-yl-vinyl)phenoxy]phenyl}propionic acid

CAS Number: 500794-88-7

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. J. Med. Chem. 2006, 49, 6635-6637

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