For research purposes only

Cat. No BA94673190

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Description of biological activity

Positive allosteric modulator (PAM), selective for the metabotropic glutamate receptor subtype mGluR5. In an assay [WO2006/123249 A2, 2006] using HEK-293 cells expressing metabotropic glutamate receptor subtype 5 (mGluR5) of rat the compound showed EC50 < 1 μmol/l.

TECHNICAL INFORMATION

(3,4-difluoro-phenyl)-[(S)-3-(3-pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone positive allosteric modulator (PAM), selective for the metabotropic glutamate receptor subtype mGluR5.

IUPAC Name: (3,4-difluoro-phenyl)-[(S)-3-(3-pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

CAS Number: 915233-07-7

Purity: > 96% chemical purity (LCMS)

1H-NMR spectrum (click to enlarge)

REFERENCES

1. ChemMedChem 2009, 4, 505-511

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