Custom synthesis

Highest qualification and experimental skills of our chemists, experience in multi-stage complex synthesis of organic, inorganic and organometallic compounds, access to chemistry databases, all necessary equipment and analytical instruments allow us to offer CUSTOM SYNTHESIS SERVICE to our clients.

We offer custom synthesis services for the following groups of complex organic compounds:

  • molecules containing multiple chiral centers, by asymmetric synthesis or using chromatographic separation of diastereomers/enantiomers;
  • polyfunctionalised molecules;
  • peptides (up to 25 amino acid residues). Non-natural amino acids can also be incorporated into the polypeptide backbone;
  • reactive, moisture-sensitive or oxygen-sensitive compounds (e.g. phosphines, their complexes with transition metals, strained compounds);
  • (poly)fluorinated compounds;
  • natural products and their analogues;
  • cyanine dyes including those absorbing in near-infrared region

In the case of novel compounds, a team of qualified chemists develop the synthetic strategy. The usual business model is “fee for service”; risk sharing agreement is preferable in the case of very complex targets not published in open chemical literature. As a matter of course, we provide biweekly intermediate reports on the work progress and also the final reports including all the detailed synthetic procedures and analytical data.

The usual scale of our syntheses of biologically active compounds is 10-1000 mg. However, larger quantities can be prepared on request. Chemical purity of the compounds we usually produce is not less than 95%. In special cases, if required by customers, we prepare compounds of >98% purity.

Please, send us your requests (chemical formulae, preferable weight, requirements to purity, optical purity etc.) to order@bioassaystandards.com.
We then promptly come back with the estimation of the price and possible lead time.

For the list of ready-to-ship bioactive reference compounds, please, refer to our Catalog

Latest added compounds

5-(4-Hydroxy-4-methyl-isoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-(3-methyl-5-trifluoromethyl-1H-pyrazol-4-ylmethyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

Selective inhibitor of MCT1 with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited.

Anti-cancer

Inhibitors

 
5-(4-chlorophenyl)-N-{[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl}pyridine-3-carboxamide

selective inhibitor of Nav1.8 sodium channel (IC50 = 3 nM); for TRPV1, P2X2/3, Cav2.2 calcium channels, KCNQ2/3 potassium channels IC50 >10 µM

Analgesic

Inhibitors

 
1-[4-chloro-3-(trifluoromethyl)benzenesulfonyl]-4-[4-(5-methyl-1H-pyrazol-1-yl)benzoyl]piperazine

inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smuf1)

Bone disorders

Inhibitors